NFL parlay picks from proven model that return 25-1
A week after taking control of the AFC South with a 38-35 shootout victory over the Seattle Seahawks, the Tampa Bay Buccaneers will face another tough test when they take on the NFC West-leading San Francisco 49ers (+3.5). San Francisco is coming off a 26-23 victory over the Los Angeles Rams on Thursday Night Football. The Buccaneers are 2-1 in the conference, while the 49ers are 4-0 against NFC foes. There are a number of intriguing matchups on the NFL’s Week 6 schedule, including Broncos vs. Jets (+7.5) in London, Rams vs. Ravens (+7), with Lamar Jackson ruled out, Seahawks vs. Jaguars (-1.5), Lions vs. Chiefs (-2.5) on Sunday Night Football and Bears vs. Commanders (-4.5) on Monday Night Football.
What other teams have value to include in Week 6 NFL parlay bets, and which side of the NFL odds should you target? Before you lock in any NFL Week 6 picks or NFL parlays, be sure to check out the NFL predictions and betting advice from SportsLine’s proven computer model.
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The model, which simulates every NFL game 10,000 times, costs well over $7,000 for $100 players among the NFL’s top-rated picks since its inception. The model is on a torrid 41-21 streak on top-rated picks dating back to 2024. Anyone tracking their NFL betting picks at sportsbooks and betting sites could have seen some strong returns.
Now, the model has scoured the NFL Week 6 odds and locked in five best NFL confident bets. If you manage to exploit his picks, you’ll get a massive payout of around 25-1. You can only see the model’s Week 6 NFL picks at SportsLine.
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Top NFL Week 6 Picks
After simulating each game 10,000 times, the model leads the Buffalo Bills (-4.5, 50) in covering against the Atlanta Falcons on Monday Night Football. The Bills are stinging after a 23-20 loss to the New England Patriots on Sunday Night Football. Buffalo, which is 8-2 in its last 10 primetime games, will look to bounce back against a 2-2 Falcons team that is coming off a bye. Atlanta defeated Washington 34-27 in Week 4.
The Bills are led by quarterback Josh Allen, who is having a solid season so far. In the loss to the Patriots, he completed 22 of 31 passes (71%) for 253 yards and two touchdowns with one interception. He has thrown for over 1,200 yards this season with nine touchdowns and two picks. Running back James Cook leads the rushing attack, carrying 90 times for 450 yards (5.0 average) and five touchdowns. The model has Buffalo winning nearly 80% of the time and covering nearly 70% of simulations. Find out what other NFL parlay picks to make here and bet on which bills to cover here:
How to Make Week 6 NFL Parlays
The model has also participated in four other NFL matchups where he believes the line is far away, including backing an underdog who he believes will not only cover, but win outright. You can only see the model’s Week 6 NFL best bets and NFL bets at SportsLine.
What are the model’s top picks in the NFL for Week 6 and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see a model’s best NFL Week 6 bets on a 41-21 run on top-rated picks, and find out.
