Clemastine fumarate promotes myelin repair in a nonhuman primate model of demyelination characterized by absent spontaneous remyelination

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
ImportanceMyelin repair represents an unmet need for the treatment of demyelinating diseases such as multiple sclerosis (MS). Clemastine fumarate has been validated as a promyelinating agent in rodents and in a first clinical trial for MS, but not in models…