SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR–IRX transcription factor signaling axis
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The acts of the National Academy of Sciences, Volume 122, number 35, September 2025.
Significantmutations in the protein Tyrosine Phosphatase SHP2 which cause noon syndrome with several lentigines (NSML) lead to the development of hypertrophic cardiomyopathy (HCM). This study shows that in the heart, when SHP2 …
