Overcoming the space clamp effect: Reliable recovery of local and effective synaptic conductances of neurons

Proceedings of the National Academy of Sciences, Volume 122, Issue 40, October 2025. <br/>SignificanceNeurons communicate by activating synapses along dendrites. To decipher the principles of neuronal coding, it is essential to recover input signals before they integrate at the soma. Traditional approaches, which often utilize a somatic …