Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceHao–Fountain syndrome is a rare neurodevelopmental disorder with no cure, where patients experience symptoms including developmental delay, dysmorphic facial features, and seizures. This syndrome is caused by loss-of-function mutations to the …