SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals

Proceedings of the National Academy of Sciences, Volume 122, Issue 31, August 2025. <br/>SignificanceChromatin regulation reshapes the physical genome of germ cells to enable meiosis. Here, we elucidate the role of the ISWI chromatin remodeler SMARCA5 in male germ cell development and meiotic progression. Loss ofSmarca5function leads to …