Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation

Proceedings of the National Academy of Sciences, Volume 122, Number 40, October 2025.
ImportanceA major mechanism for regulating blood pressure involves the relaxation of small resistance vessels. If the pressure is too high, the endothelium of the vessels signals the smooth muscle cells (SMC) to relax. This endothelium-dependent relaxation…