SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor

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Proceedings of the National Academy of Sciences, Volume 122, Number 50, December 2025.
SignificanceHuman enterovirus A71 (EV-A71) is a major cause of hand, foot and mouth disease that poses a global threat to human health. Despite intensive research, the cellular factors essential for EV-A71 infection remain enigmatic.

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