Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair

Proceedings of the National Academy of Sciences, Volume 122, Issue 31, August 2025. <br/>SignificanceBacteria encode a variety of reverse transcriptases (RTs) that evolved from mobile group II intron RTs to perform different cellular functions. A previous study found that one such domesticated group II intron–like RT (G2L4 RT) functions in …