Structural insights into the G-protein subtype selectivity revealed by human sphingosine-1-phosphate receptor 3–Gq complexes

Proceedings of the National Academy of Sciences, volume 122, number 47, November 2025.
ImportanceSphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates many essential immune functions via S1P receptors (S1PR1-5). Among them, S1PR3 plays an essential role in inflammatory responses by activating Gαq signaling…