Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F

Proceedings of the National Academy of Sciences, Volume 122, number 26, July 2025.
Signistivecyclin F is an essential enzyme that intervenes in cell division by lowering the activity of the transcription factor E2F. Unlike other members of the Cycline family, Cycline F did not activate the cycline-dependent kinases, but it rather …