Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
Significance The tumor suppressor PP2A is known to promote c-Myc degradation, but dephosphorylated c-Myc at Thr58 escapes FBXW7-dependent degradation, creating a paradox in tumor biology. We show that the PP2A-B55α complex resolves this paradox by…