Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations

Proceedings of the National Academy of Sciences, Volume 123, Issue 7, February 2026. <br/>SignificanceDopamine signaling underlies learning, motivation, and behavioral flexibility, yet how the presynaptic release machinery shapes these functions remains poorly understood. This study identifies Synaptogyrin-3 (Syngr3) as a regulator of dopamine …