Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceThe synthetic lethality of E2F3 inactivation in RB-deficient small cell cancer cells is established. E2F3 dependency is shared across RB-deficient cells originating from multiple tissues. The requirement for E2F3 in RB-deficient small cell …