T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceEstablishing immunological tolerance to self and environmental antigens is critical for homeostasis. In the intestine, both dietary and microbiota-derived antigens are encountered by the immune system, which deploys a variety of mechanisms to …