Targeting C1q signaling in fibro-adipogenic progenitors prevents regenerative fibrosis of aged muscle

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceFibrosis in skeletal muscle impairs regeneration and function, especially with age, severe injury, or degenerative disease. In healthy muscle, fibro-adipogenic progenitors (FAPs) support muscle repair. However, under abnormal conditions, FAPs …