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Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. <br/>SignificanceAdhesion G protein–coupled receptors (aGPCRs) remain among the least characterized GPCR subfamilies, with the latrophilin family predominantly studied in neuronal contexts. In this study, we identify ADGRL2 as an adhesion GPCR functioning as a …
