The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins

Proceedings of the National Academy of Sciences, Volume 122, Issue 37, September 2025. <br/>SignificanceTIR (Toll/interleukin-1 receptors) domain proteins perform immune signaling across the Tree of Life. TIR domains are enzymes that can process NAD+to generate diverse small molecule signals. In order to better understand TIR-based signaling, …