The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. <br/>SignificanceAdhesion G protein–coupled receptors (aGPCRs) are understudied cell-surface receptors with multidomain extracellular regions (ECRs). aGPCRs are essential for development, and they are dysregulated in developmental diseases and cancer. Our …