The fetal hydrops–associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel

Proceedings of the National Academy of Sciences, Volume 122, Issue 33, August 2025. <br/>SignificanceGenetic deletion studies have revealed the diverse cellular, physiological, and pathophysiological roles of the mechanically activated PIEZO1 ion channel. However, whether these functions are directly mediated by its mechanosensitivity has …