The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificanceSince its integration into mammalian genomes 100 Mya, theHEMO(Human Endogenous MER34 ORF) retroviral envelope gene has been conserved under selective pressure in all simian primates and some carnivores, remaining the only full-length ORF in …