Prostaglandin E2-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificanceRegulatory T cells (Tregs) are enriched in the tumor microenvironment (TME) and contribute to immune evasion. These tumor-infiltrating Tregs (TI-Tregs) are highly suppressive and express a unique set of genes, which are conserved across …