The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function

Proceedings of the National Academy of Sciences, Volume 122, Issue 28, July 2025. <br/>SignificanceIntellectual disability represents a core clinical manifestation of ZC4H2-associated rare disorder (ZARD), yet the underlying synaptic etiology remains elusive. In this study, with a conditional knockout mouse model depleting its pathogenic …