The prion-like characteristic of ORF3 contributes to virion release and pathogenesis of hepatitis E virus
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Proceedings of the National Academy of Sciences, Volume 122, Number 49, December 2025.
ImportancePrions and prion-like proteins can form self-propagating protein aggregates that have been identified in animals, plants, and various microorganisms. Here we demonstrate that HEV-ORF3 forms self-propagating aggregates similar to prions, which is…
