An autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026.
SignificanceApproximately 5 to 15% of the North American population has thePTPN221858C>T allele, which has been linked with numerous autoimmune diseases and is considered the highest non-HLA risk allele for autoimmunity. Due to this link, thePTPN22…