Bears vs. 49ers prediction, odds, time: ‘Sunday Night Football’ picks by proven model

A potential playoff preview takes place on “Sunday Night Football” in NFL Week 17 as the Chicago Bears visit the San Francisco 49ers. Both teams are 11-4 and have already clinched playoff spots, but each still has a chance to become the NFC’s top seed if they win. Chicago is coming off a 22-16 win Saturday over Green Bay, while San Francisco is coming off a 48-27 win over Indianapolis on Monday. George Kittle (ankle) is listed as questionable.

Kickoff will be at 8:20 p.m. ET from Levi’s Stadium in Santa Clara, California. These teams have alternated wins and losses over their last eight meetings, with San Fran winning in the last match. The latest 49ers vs. Bears odds have San Francisco as a 3.5-point favorite, while the over/under in total points scored is 51.5 via DraftKings Sportsbook. Before making any Bears vs. 49ers picks, check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, costs well over $7,000 for $100 players among the NFL’s top-rated picks since its inception. The model entered Week 17 with a 53-37 record on top-rated picks dating back to 2024. Anyone following him NFL betting chooses to sports betting and on betting sites, returns could have been high.

Now, the model has set its sights on the 49ers versus the Bears. You can visit SportsLine now to see the picks. Here are the NFL odds and betting trends for the Bears vs. Niners:

Why the Bears can cover

Chicago is undefeated against the spread in its last six games and also has a two-day rest advantage after playing last Saturday, while San Francisco is coming off an “MNF” appearance. The Niners are just 6-8 ATS in their last 14 games when at a disadvantage at rest. On the field, the Bears lead the NFL in the stat most correlated to wins and losses, turnover differential. Chicago is plus-21 in that regard, while the second-place team is just plus-15. Chicago forced the most turnovers (31) and committed the second most (10). When the Niners lose the turnover battle this season, they are just 3-4 ATS. Find out which team to support on SportsLine.

Why the 49ers can cover

On a five-game winning streak, San Francisco leads the NFL in points per game, points per drive and 3rd down offense during this streak, and each of the five wins have been by double digits. The offense has been unstoppable over the last two games in particular, as the Niners are just the fifth team in the last 75 years to go on consecutive outings without throwing the ball. Although he does not qualify for statistical rankings due to missing time, Brock Purdy leads the NFL in QBR and is top five in touchdown percentage, completion percentage and passer rating. Additionally, the 49ers are 4-0 both straight and against the spread in prime time in 2025. Find out which team to support at SportsLine.

How to make Bears vs. 49ers picks

SportsLine’s model has simulated Niners vs. Bears 10,000 times and is over the total, projecting a combined 53 points. It also indicates that one side of the gap hits more than 50% of the time. You can only get the pick at SportsLine.

So who does the Bears win against the Niners, and which side of the spread hits in more than 50% of simulations? Visit SportsLine now to see which side of the 49ers vs. Bears spread to jump on, all from the advanced model that has ended up over $7,000 on its NFL picks since its inception, and find out.