The transcription factor Bcl11a is essential for B-1a cell maintenance during aging

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Proceedings of the National Academy of Sciences, Volume 122, number 27, July 2025.
The cells of Meaning-1a are essential innate sentries that produce natural IgM for rapid immunity, but the way they are maintained during aging remains uncertain. We identify BCL11A as a critical regulator of the survival of B-1A cells in aging mice. Elderly woman B-1a …

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