Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. <br/>SignificanceOsteoarthritis, a leading cause of disability in aging populations, is marked by joint cartilage degeneration and mitochondrial dysfunction in chondrocytes. Our study uncovers the critical role of the mitofusin-2 (MFN2)/sarcoendoplasmic …