Slippage reconfiguration of trinucleotide repeat hairpins impedes resolution by human replication protein A

Proceedings of the National Academy of Sciences, Volume 123, Issue 4, January 2026. <br/>SignificanceTandem CTG/CAG repeats destabilize genomes and promote neurodegenerative disease through secondary structure formation, yet how single-stranded DNA-binding proteins counteract these structures remains unclear. Using single-molecule …