CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma

Proceedings of the National Academy of Sciences, Volume 122, Issue 39, September 2025. <br/>SignificanceThis study identifies the adenosine triphosphatase (ATPase) valosin-containing protein valosin-containing protein (VCP) as a potential therapeutic target in cholangiocarcinoma (CCA). Inhibition of VCP with drugs induces senescence in cancer …