Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation

Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceAs the first transcriptional milestone in life, zygotic genome activation (ZGA) driven by pioneer factors is a hallmark of totipotency, enabling embryos to transition from maternal to zygotic control. Yet, the mechanisms governing the …