Transcriptional condensates encode a “golden mean” to optimize enhancer–promoter communication across genomic distances

Proceedings of the National Academy of Sciences, Volume 122, Issue 43, October 2025. <br/>SignificanceCells can assemble transcription factors and other cofactors (proteins that control gene activity) into droplet-like clusters to help distant DNA regulatory elements (i.e., enhancers) interact with gene promoters. Our simulations reveal a “…