TRIM21enhances IL-17A signaling and drives autoimmune myocarditis by promoting TRAF3 lysosomaldegradation in cardiac fibroblasts

Proceedings of the National Academy of Sciences, Volume 123, Number 6, February 2026.
ImportanceMyocarditis is a life-threatening disease that can progress to dilated inflammatory cardiomyopathy (DID) and heart failure, but current therapies do not target the transition to chronic cardiac injury. Understanding the mechanisms that lead…