Structural insight into the CUB2 domain’s role in enteropeptidase-mediated trypsinogen activation

Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
SignificanceAberrant activation of trypsinogen disrupts proteolytic homeostasis, but the precise structural and functional mechanisms governing its normal activation by enteropeptidase (EP) remain poorly understood. Our study fills this critical gap by…