k5-mediated microglial ferroptosis drives ischemic white matter damage via the Nfatc4–Clptm1l axis

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceThe therapeutic potential of targeting the Erk5–Nfatc4–Clptm1l axis in ischemic white matter damage was first proved, laying a solid foundation for the clinical translation of Erk5 inhibitors as a treatment strategy. Our study provides …