A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia

Proceedings of the National Academy of Sciences, Volume 123, Number 1, January 2026.
ImportanceApolipoprotein AV (APOA5) reduces plasma triglyceride levels by binding to the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its ability to block lipoprotein lipase, but our understanding of the important APOA5 sequences and how…