RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation

Proceedings of the National Academy of Sciences, Volume 123, Number 15, April 2026.
SignificanceReceptor-interacting protein kinase 1 (RIPK1) is a central regulator of apoptosis, necroptosis, and inflammation, with distinct functions determined by its scaffolding role and kinase activity. Post-translational modifications of RIPK1-…