Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis
Proceedings of the National Academy of Sciences, volume 122, number 25, June 2025.
Meaning of your study identifies a role of UBR4 in the regulation of mitochondrial quality, cellular aging and tumor growth in pulmonary adenocarcinoma (LUAD). UBR4 allows mitophagy to maintain healthy mitochondria and support adaptation to stress. Loss of causes UBR4 …
