Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
ImportanceTo metastasize, cancer cells migrate from the primary tumor through dense tissues to spread to distant organs. During this journey, as cells squeeze through thin passages in the tissue, the membrane surrounding the cancer cell’s nucleus can burst,…