The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging

Proceedings of the National Academy of Sciences, Volume 123, Number 14, April 2026.
Importance The way HIV-1 selectively packages its genome (gRNA) into virions is poorly understood. To probe this, we replaced the viral nucleocapsid (NC) protein with heterologous RNA-binding domains (RBDs) from the hnRNP and SR cellular protein families. …