G-quadruplexes as a source of vulnerability in BRCA2-deficient granule cell progenitors and medulloblastoma

Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. <br/>SignificanceThis study highlights a specific source of endogenous DNA replication stress, G-quadruplexes (G4s), that can increase genome instability in BRCA2-deficient cerebellar granule cell progenitors (GCPs), leading to medulloblastoma. BRCA2 is …