VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. <br/>SignificanceEarly development of the human placenta is essential for pregnancy success, yet the mechanisms that guide placental lineage specification remain poorly defined. Using human stem cells, we show how signaling pathways and chromatin remodeling …