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Nonsense-mediated decay controls a negative feedback loop in innate immune sensing

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Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceNonsense-mediated decay (NMD) is a translation-dependent mRNA decay pathway that plays an important role in shaping the transcriptome. In this manuscript, we show that sensing of viral RNA or transfected dsRNA, through intracellular receptors …

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