DIRAS2 modulates MAPK pathway–mediated ferroptosis to regulate excitation/inhibition balance and seizure susceptibility

Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceThe role of DIRAS2 in epilepsy remains unexplored. In this study, we demonstrate that DIRAS2 alleviates epileptic seizure susceptibility and activity and regulates the excitatory/inhibitory balance. Mechanistically, DIRAS2 suppresses …