Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificanceMutations in transmembrane domains (TMDs) of cytokine and immune receptors often cause aberrant, ligand-independent signaling linked to diverse malignancies, but the mechanisms are largely unknown. This paper reveals an oncogenic mutation …