eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling

Proceedings of the National Academy of Sciences, Volume 122, Issue 45, November 2025. <br/>SignificanceProkaryotes can detect and respond to extracellular ATP (eATP) to initiate specific functional outputs. Our research identified the receptor PA2072 in the pathogenPseudomonas aeruginosa, with its periplasmic CHASE4 domain serving as a …