Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission

Proceedings of the National Academy of Sciences, Volume 122, number 37, September 2025.
significant significant is an irreversible cause of blindness, with unsatisfied medical requirements for innovative prevention and treatment strategies. Here, we have shown that sorting Nexin 3 (SNX3) was significantly regulated upwards in retinal myeloid cells …