STAR/STARD1: A mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy

Proceedings of the National Academy of Sciences, Volume 122, Issue 41, October 2025. <br/>SignificanceCholesterol import into mitochondria is a pivotal first step in steroid hormone and bile acid synthesis. For decades, the mechanism by which the steroidogenic acute regulatory protein (STAR/STARD1) mediates this process has remained …