Small molecule–constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins

Proceedings of the National Academy of Sciences, Volume 123, Number 13, March 2026.
Significance We report the applicability of a CLIPS (chemical linking of peptides on scaffolds) chemistry-based strategy to miniaturize an anti-influenza hemagglutinin (HA) antibody in the design of stable and functional bicyclic peptides by fusing…