Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides

Proceedings of the National Academy of Sciences, Volume 123, Number 14, April 2026.
ImportanceRibosomally synthesized and post-translationally modified peptides (RiPPs) are a superfamily of natural products that exhibit antibiotic, antifungal, anticancer, and metal-binding activities. Their biosynthesis typically follows a common logic…